There exists a release of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors in the dorsal horn to lower afferent pain transmission and produce analgesia. Consequently, drugs like clonidine that target alpha-two receptors can influence the transmission of pain. Could possibly be presented as monotherapy or https://socialbuzzfeed.com/story5308121/examine-this-report-on-onolidine