Transcription factors are involved in a large number of human diseases such as cancers for which they account for about 20% of all oncogenes identified so far. For long time. with the exception of ligand-inducible nuclear receptors. transcription factors were considered as “undruggable” targets. https://www.jmannino.com/quick-save-Arcade-Smokey-Bear-Belt-p10222-great-pick/