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Opioid action is due to both lower affinity binding from the parent compound and better affinity binding from the O-demethylated metabolite M1 to µ-opioid receptors. In animal versions, M1 is as much as six periods additional strong than tramadol in producing analgesia and 200 occasions additional powerful in µ-opioid binding. https://buy-co-codamol60134.educationalimpactblog.com/54448892/tramadol-50-mg-online-can-be-fun-for-anyone

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